The Triple Helix model was originally proposed by Etzkowitz and Leydesdorff ( 1995) to explain the dynamic interactions between academia, industry and government for fostering entrepreneurship, innovation and economic growth in a knowledge-based economy (Etzkowitz and Leydesdorff 2000). Among the most popular conceptual frameworks used in innovation studies, the Triple Helix and Quadruple Helix models of innovation are two seemingly competing concepts that have been broadly applied in empirical investigations in innovation studies. Innovation studies are teeming with new concepts that attempt to capture the new features of contemporary society. Third, our comparison of the two models shows that they are largely supplementary to each other when analysing innovation processes in contemporary society, providing a ground for potential synergy building between the two helix models. Second, we provide a systematic comparison of both the advantages and weaknesses of the two models, and this may help researchers choose suitable helix models as conceptual/analytical tools in their empirical innovation studies. Our major findings are as follows: First, reviewing the extant literature applying the two helix models for identifying research gaps, we discover that these studies were influenced by three views on the relations between the two models that were located on a continuum between two extreme ends-namely, isolation versus integration of the two models. To bridge the research gap, this paper compares the models from the perspectives of how they were introduced and discussed in the literature and improved and how useful they are in addressing the innovation processes in contemporary society. We discern that the cause of this research challenge is a lack of systematic comparison of the two models. Such a situation can confuse newcomers to the field in terms of which helix model to apply in their empirical research. There are diverse interpretations of helix models in empirical studies that apply them, but these sometimes deviate from the original theses of the models. While the Triple Helix and Quadruple Helix models are popular in innovation studies, the relations between them have not been addressed extensively in the literature.
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